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GENERIC NAME: amitriptyline
BRAND NAME: Endep (Elavil: This brand name drug is no longer available in the U.S.)

DRUG CLASS AND MECHANISM: Amitriptyline is an antidepressant drug. Depression is an all-pervasive sense of sadness and gloom. It is believed that in some patients with depression, abnormal levels of neurotransmitters (chemicals that nerves use to communicate with each other) may relate to their depression. Amitriptyline elevates mood by raising the level of neurotransmitters in nerves of the brain. Amitriptyline was approved by the FDA in May 1983.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 10, 25, 50, 75, 100, and 150mg.

STORAGE: Amitriptyline should be stored at room temperature in a tight, light resistant container. Avoid storage at temperatures above 30°C (86°F).

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GENERIC NAME: nortriptyline
BRAND NAMES: Pamelor, Aventyl

DRUG CLASS AND MECHANISM: Nortriptyline is in the class of drugs called tricyclic antidepressants (TCAs) and is used for treating depression. Other drugs in the same class include amitriptyline (Endep, Elavil), clomipramine (Anafranil), doxepin (Sinequan), imipramine (Tofranil), trimipramine (Surmontil), amoxapine (Amoxapine), desipramine (Norpramin), and protriptyline (Vivactil). Individuals with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves. Like all TCAs, nortriptyline increases levels of norepinephrine and serotonin, two neurotransmitters, and blocks the action of acetylcholine, another neurotransmitter. It is believed that by restoring the balance of these different neurotransmitters in the brain depression is alleviated (for example, the mood is elevated). Nortriptyline was approved by the FDA in November 1964.